Trichothecenes compromise the blood brain barrier, innate immune system, inflammatory pathways, nervous and endocrine systems, and make micro glia overly sensitive. They also impact the gut in several ways: compromising tight junctions, and compromise nutrient absorption.

The mycotoxin Citrinin affects all the main organs, including the bone marrow, liver, kidney, and mitochondrial respiratory chain. Citrinin and Gliotoxin both inhibit IL-10. IL-10 can block TNFA and IL-6, both important inflammatory pathways. Citrinin was significantly associated with neutrophilia, squamous cell carcinoma, Fanconi anemia, leukemia, hepatoblastoma, and fatty liver diseases.

Ochratoxin A negatively impacts a significant number of pathways related to detoxification, oxidative stress, heme biosynthesis, and iron regulation. Research has shown that many commonly available compounds can help counteract these negative effects.

Ochratoxin A effects pathways that lead to many issues like : neurodegeneration, brain inflammation, iron dysregulation, POTS, Glial Cell Reactivity, Mast Cell Activation, Mitochondrial Dysfunction, Metabolic Dysfunction, and Ferroptosis (un mitigated cell death), Hypoxia, and massive fatigue.