GPX4 - Glutathione Peroxidase4, is the only glutathione peroxidase gene located exclusively in the mitochondria. It takes the exhaust products of SOD2, hydrogen peroxide, and turns it into water. If mutated, inhibited, or non functioning, GPX4, can lead to ferroptosis - unmitigated cell death.

Andrographis is an herb commonly used to treat colds and respiratory infections, but also has many other potential applications. Andrographis is a potent inhibitor of NOS2, regulates inflammatory genes like NFKB, NLPR3, TNFA, and also induces Heat Shock Protein 70 (HSP70) increases cellular resistance to oxidative and thermal stress.

Arg1 is a key gene needed in the urea cycle to clear ammonia which can cause brain fog. There are many common herbs used in various anti inflammatory and anti oxidant therapies that inhibit Arg1. If you suffer from brain fog, this article may be interesting to explore.

Anemia of inflammation is a common condition experienced by those who suffer from chronic illnesses, such as mold exposure, ME / CFS, or Long Covid. Elevations in Hepcidin, induced by elevations in the inflammatory marker IL-6, lower absorption of dietary iron.

Cardiovascular disease continues to be a primary issue in many countries. This article explores some of the mechanics behind arterial wall plaque formation and why the French seem to have some sort of protection from high fat diets.

Interesting studies provide clues on some of the potential contributing factors to neurological disorders like Alzheimer’s, Parkinsons, and ALS. Recent studies link proximity to golf courses at risk for Parkinsons. Meanwhile, links to Cyanobacteria and BMAA toxicity due to bat consumption in Guam also provide clues on the cascade dysfunction that leads to neurological disorders.

The inner membrane of the mitochondria, is home to cardiolipin, a very special component.

NQO1 is a critical gene performing a variety of functions from detoxification of volatile organic compounds, recycling NAD and coQ10, neutralizing super oxide, and recycling NAD/NADPH.

Home air filter systems can be a valuable addition to our lives and homes to ensure the air we breathe has less of a toxin load. In this article, i discuss, how to do this on the cheap, using a box fan and home furnace filters.

The Blue Zone Diets. Why folks in Blue Zones have lower rates of dimentia and Alzheimers. Serine and PHGDH. Read on.

SULT genes, principally SULT1A1, are used in the detoxification of many compounds. Its also at the cross-roads for sulfur related issues for many.

Chrysin, extracted from Passion Flower, was a topic a Long Haul Covid Clinics Webinar series. I wanted to add some things to provide a more accurate context about its mechanisms of action.

Many use epsom salt baths to ‘relax and recharge’, or simply help our mind become less stressed. What is going, why is this happening ? We will explore the NAD+/NADPH pathway, magnesium, the QPRT gene, quinolinic acid, and one of many reasons why oxidative stress matters (alot).

Sources of proanthocyanidins like Pycnogenol, Pine Bark, Grape Seed Extract, and Red Rice Bran offer a wide range of significant health benefits. These benefits range across a variety of areas from circulation, oxidative stress, inflammation, and gut microbiome benefits.

Learn how to use your herbs and spices to modulate key inflammatory and immune pathways. What to look out for to prevent inhibition of key immune genes like IL-10 on a long term basis.

Salicylate sensitivity can account for a variety of mystery ailments, and food sensitivities. Understanding how to test and evaluate, and then move forward with a dietary and supplement plan on how to resolve is not easy.