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HEALTH/NUTRITION Michael Kreder HEALTH/NUTRITION Michael Kreder

A Metabolic Switch (PPAR-Gamma), and Its Connection To : Glucose Uptake, Lactic Acid, ATP Production, Mast Cell Activation, NFKB/Inflammation, Oxidative Stress, and Endothelial Function

Managing blood glucose has received alot of attention, investment, and news coverage for a long time. And not without controversey from Ray Peat, and his beliefs, to the Keto and Plant Based diet alternatives. Here we look at key genes that regulate glucose uptake - for both those that struggle with high blood glucose, but also for athletes that use glucose for energy production in the Krebs (Citric Acid) Cycle. Further we link in PPAR-Gamma that exerts strong influence across this and many more functions (mitochondrial biogenesis, mast cell activation, oxidative stress, eye health, metabolic processes, etc).

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CHRONIC ILLNESS, HEALTH/NUTRITION Michael Kreder CHRONIC ILLNESS, HEALTH/NUTRITION Michael Kreder

All About B12: High Serum B12 and Which Form of B12 Is Best ?

High serum B12 in chronic illness might reflect a deficiency caused by oxidative stress, deficiencies in B2, Glutathione, Molybdenum, Iodine, sulfur, or Selenium. Aberrant excess nitric oxide from nNOS (NOS1) and iNOS (NOS2) degrades B12 rendering it useless. Hydroxocobalamin inhibits nNOS (NOS1) and iNOS (NOS2). nNOS and iNOS are often upregulated from bacterial and viral infections, and a cascade of inflammation starting in the microbiome. Lowering oxidative stress with a diet rich in anti oxidants can be helpful too.

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Low Iron / Anemia of Inflammation (High IL-6)- By Activation Of Hepcidin.  Cobalt and Aluminum Effects On Iron Homeostasis

Anemia of inflammation is a common condition experienced by those who suffer from chronic illnesses, such as mold exposure, ME / CFS, or Long Covid. Elevations in Hepcidin, induced by elevations in the inflammatory marker IL-6, lower absorption of dietary iron.

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