High serum B12 in chronic illness might reflect a deficiency caused by oxidative stress, deficiencies in B2, Glutathione, Molybdenum, Iodine, sulfur, or Selenium. Aberrant excess nitric oxide from nNOS (NOS1) and iNOS (NOS2) degrades B12 rendering it useless. Hydroxocobalamin inhibits nNOS (NOS1) and iNOS (NOS2). nNOS and iNOS are often upregulated from bacterial and viral infections, and a cascade of inflammation starting in the microbiome. Lowering oxidative stress with a diet rich in anti oxidants can be helpful too.

Folic Acid! Why it was put in food, what it does, and whom are most sensitive to it and why!!!!

Riboflavin is a critical nutrient used in many different systems: anti oxidant, heme synthesis, neurotransmitter metabolism, detoxification, mitochondria energy production, and activation of other vitamins like B6 to name just a few.

All about the 8 different forms of Vitamin E - Tocotrienols and Tocopherols. Each of the 4 types of Tocotrienols and 4 types of Tocopherols offer unique benefits. From protecting against nitrative stress, neural protection, mitochondrial benefits, or cholesterol lowering effects - each plays a special role.

Glutathione is often considered the master anti oxidant - but it also plays other key roles too, as an important cofactor, and an immune regulator.

Some basic facts around methylation, the prevalence of mutations on MTHF1298c and MTHFR C677T.

Biotin deficiency and the connections to candida, diet, genetics, and stress.

Understanding the mechanics of Herxheimer reactions can give us clues about what may be causing them and how to limit them during detoxification.

Herbicides and pesticides are commonly used in the food supply chain in the United States that are banned in other countries. Could this be behind some of feel better when we travel over-seas ?

Understanding different fast acting ways to help regulate your nervous system, engage the parasympathetic branch of your nervous system, improve your sleep and HRV.

Schisandra is an herb long used in chinese medicine - for cholesterol, and triglyceride improvement. Learn the detailed effects by Schisandra on lipid metabolism, acetyl aldehyde clearance, detoxification, and anti oxidant genes.

Copper is an important nutrient used as a cofactor is genes associated with anti oxidant systems, and immune function to name a couple. Copper also, has specific considerations to help absorption, as well as toxicity in excess.

Arg1 is a key gene needed in the urea cycle to clear ammonia which can cause brain fog. There are many common herbs used in various anti inflammatory and anti oxidant therapies that inhibit Arg1. If you suffer from brain fog, this article may be interesting to explore.

Anemia of inflammation is a common condition experienced by those who suffer from chronic illnesses, such as mold exposure, ME / CFS, or Long Covid. Elevations in Hepcidin, induced by elevations in the inflammatory marker IL-6, lower absorption of dietary iron.

Cardiovascular disease continues to be a primary issue in many countries. This article explores some of the mechanics behind arterial wall plaque formation and why the French seem to have some sort of protection from high fat diets.

The inner membrane of the mitochondria, is home to cardiolipin, a very special component.