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Chrysin (Often extracted from Passion Flower)
Chrysin, extracted from Passion Flower, was a topic a Long Haul Covid Clinics Webinar series. I wanted to add some things to provide a more accurate context about its mechanisms of action.
Magnesium, Epsom Salt Baths, & The Production of NAD+ and Reduction of Neurotoxic Quinolinic Acid
Many use epsom salt baths to ‘relax and recharge’, or simply help our mind become less stressed. What is going, why is this happening ? We will explore the NAD+/NADPH pathway, magnesium, the QPRT gene, quinolinic acid, and one of many reasons why oxidative stress matters (alot).
The Wonders of Proanthocyanidins: Marine Pine Bark, Pycnogenol, Grape Seed Extract, and Red Rice Germ
Sources of proanthocyanidins like Pycnogenol, Pine Bark, Grape Seed Extract, and Red Rice Bran offer a wide range of significant health benefits. These benefits range across a variety of areas from circulation, oxidative stress, inflammation, and gut microbiome benefits.
Herbal Approaches To Modulating iNOS, IL-6, TNFA, COX-2, and IL-10
Learn how to use your herbs and spices to modulate key inflammatory and immune pathways. What to look out for to prevent inhibition of key immune genes like IL-10 on a long term basis.
Salicylate Sensitivity
Salicylate sensitivity can account for a variety of mystery ailments, and food sensitivities. Understanding how to test and evaluate, and then move forward with a dietary and supplement plan on how to resolve is not easy.
Alzheimer’s, Neurodegeneration and Oxidative Stress
For middle aged folks, nothing can be more frightening than the looming prospect of cognitive decline and the potential of Alzheimer’s Disease and Neuro Degeneration.
Morning Blue Light Therapy for TBI, Alzheimer’s, and Glymphatic Drainage in ME/CFS and Long Haul
Morning Blue Light Therapy has long standing notable published research that it helps TBI patients improve, and more recently Alzheimer’s patients improve cognitive function, while also activating brain circuits associated with Glymphatic Drainage by modulating Aquaporin-4.
Do You Feel Good on Coffee or Doxycycline? It May Be a Clue!
Both coffee and Doxycycline are capable of scavenging multiple reactive oxygen species, thus providing significant antioxidant activity. If you feel better after ingesting either one, it could be because of increased oxidative stress in your body.
Low Vitamin D: Ties To Osteoporosis and Biological Age
Understanding what are body needs to digest and process Vitamin D so it can be converted into useable forms is no simple process. Many cofactor nutrients are needed in addition to solid digestive health. Some of these are B2, B3, B6, B7, B12, Zinc, Copper, Manganese, Molybdenum, Selenium, Iodine, Lipoic Acid, Glycine, and more.
Fucoidan: The Magic of Brown Seaweed
The health benefits associated with Brown Seaweed, and one of its principal components - Fucoidan - are astounding. Known as an anticoagulant and potent anti-oxidant, there are many other benefits as well.
DDT and Marijuana: Sounds Like Trouble
DDT and its is being found in the urine of folks exposed to marijuana. DDT and its metabolites are found in the farms of where marijuana is grown, as well as in the marijuana itself.
Mycotoxins: Trichothecene
Trichothecenes compromise the blood brain barrier, innate immune system, inflammatory pathways, nervous and endocrine systems, and make micro glia overly sensitive. They also impact the gut in several ways: compromising tight junctions, and compromise nutrient absorption.
High Dose Vitamin C Considerations
Key health considerations for high dose vitamin c therapy include health of anti oxidant systems, state of oxidative stress load, iron status, oxalate status, and if helps is needed to recycle BH4 and methylfolate.
Mycotoxins: Zearalenone
The mycotoxin zearalenone (ZON) is produced by Fusarium mold species. I chose to highlight this mycotoxin following my blog articles on Ochratoxin A (OTA) for three reasons. First, I often see ZON elevated along with OTA on urine-based mycotoxin tests. Second, when it comes to food contamination, ZON and OTA are found on the same grains. Third, it’s effects on the body are significant, given that it inhibits copper transporters, depletes vitamin B2, causes blood glucose dysregulation, and blocks a key gene (GPX4) which can lead to high mitochondrial oxidative stress and Ferroptosis.
Mycotoxins: Citrinin and Gliotoxin
The mycotoxin Citrinin affects all the main organs, including the bone marrow, liver, kidney, and mitochondrial respiratory chain. Citrinin and Gliotoxin both inhibit IL-10. IL-10 can block TNFA and IL-6, both important inflammatory pathways. Citrinin was significantly associated with neutrophilia, squamous cell carcinoma, Fanconi anemia, leukemia, hepatoblastoma, and fatty liver diseases.
Mycotoxins 101: Testing, Binders, & Detox
Mycotoxin exposure is synonymous with chronic illness, ME / CFS, and Long Haul Covid. Approximately 50-75% of the folks that find me test over the 95% for at least one mycotoxin. Mycotoxins cause organ damage, oxidative stress, neurodegeneration, and some lead to blood glucose issues and diabetes, while others cause iron dysregulation and low ferritin.